PURPOSE:To report the localization of a gene causing drusen and macular degeneration in a previously undescribed North American family. METHODS:Genetic mapping studies were performed using linkage analysis in a single family with drusen and atrophic macular degeneration. RESULTS:The clinical manifestations in this family ranged from fine macular drusen in asymptomatic middle-aged individuals to atrophic macular lesions in two children and two elderly patients. We mapped the gene to chromosome 6q14 between markers D6S2258 and D6S1644. CONCLUSIONS:In a family with autosomal dominant (...) drusen and atrophic macular degeneration, the gene maps to a 3.2-cM region on chromosome 6q14. This locus appears to be distinct from, but adjacent to, the loci for cone-rod dystrophy 7 (CORD7) and North Carolina macular dystrophy (MCDR1). Future identification of the gene responsible for the disease in this family will provide a better understanding of macular degeneration. (shrink)

The problem of contradictions in the life of society has to do both with the theory of dialectics and with sociological research. Although it is impossible to separate these two aspects, the present paper will give major attention to the former aspect, that is, analysis of the specific manifestations of the universal dialectical law of the unity and struggle of opposites under the conditions of a socialist society.

Zeno's famous paradox of the flying arrow, and the statements made in efforts to solve it by Hegel and Engels to the effect that a moving body is, at a given instant, both in and not in a given place, reveal, on the one hand, the objective contradictoriness of motion and, on the other, the difficulty of explaining it within the framework and method of formal logic. The elevation of the laws of formal logic to an absolute, and the exaggeration (...) of its role have led certain writers to deny the truth of Hegel's and Engels' statement. It was shown that no body can simultaneously be and not be in a given place, and that, in describing motion, one should, instead of employing this mode of expression, merely say that the body is shifting, and successively passes one point after another. This passage is motion as an objectively non-contradictory process. (shrink)

Point-of-care testing (POCT) is a sensitive, specific and rapid form of testing for the presence of HIV antibodies. Post-exposure prophylaxis for HIV infection can reduce seroconversion rates by up to 80%. Needlestick injuries are the second commonest cause of occupational injury in the NHS and 20% of these occur during operations. In the NHS, in order to protect staff and patients from the risk of bloodborne viruses such as HIV, it is mandatory to report such injuries; however, numerous studies have (...) shown that many groups, particularly doctors, are reluctant to do so. This article outlines the arguments for and against the introduction of preoperatively seeking consent from patients to have their blood tested for HIV via POCT in order to improve the reporting rates of needlestick injuries incurred during surgery and to protect staff from infection. (shrink)

We examine two different descriptions of the behavioral functions of the hippocampal system. One emphasizes spatially organized behaviors, especially those using cognitive maps. The other emphasizes memory, particularly working memory, a short-term memory that requires iexible stimulus-response associations and is highly susceptible to interference. The predictive value of the spatial and memory descriptions were evaluated by testing rats with damage to the hippocampal system in a series of experiments, independently manipulating the spatial and memory characteristics of a behavioral task. No (...) dissociations were found when the spatial characteristics of the stimuli to be remembered were changed; lesions produced a similar deficit in both spatial and nonspatial test procedures, indicating that the hippocampus was similarly involved regardless of the spatial nature of the task. In contrast, a marked dissociation was found when the memory requirements were altered. Rats with lesions were able to perform accurately in tasks that could be solved exclusively on the basis of reference memory. They performed at chance levels and showed no signs of recovery even with extensive postoperative training in tasks that required working memory. In one experiment all the characteristics of the reference memory and working memory procedures were identical except the type of memory required. Consequently, the behavioral dissociation cannot be explained by differences in attention, motivation, response inhibition, or the type of stimuli to be remembered. As a result of these experiments we propose that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material that is to be processed by that memory. (shrink)

Brodtkorb's "phenomenological reading" discusses the conceptually resistant realities, "World," "Body," "Others," and "Time," as they are interpreted in Moby Dick, and are focused by Melville in the inscrutable meaning of the white whale. "Mediation" is the key to interpretation, and, thus, the hero of the novel is Ishmael, who understands that the whale's meaning is constituted anew by each perceiver; Ishmael's mental life is a succession of attitudes—a series of "incantations"—which matches existence as process. From this phenomenological point of view, (...) Ahab's rigid interpretation of the whale as an allegory of divine malevolence is doomed, since allegory is a static mediated category, untrue to process. Yet this processional epistemology is itself in doubt if, as Brodtkorb admits, the uncertainty of the inscrutable is itself in question; and this doubt allows for the potential correctness of even Ahab's reductive allegorization. Thus, while Brodtkorb's phenomenology is a very sensitive instrument for indicating the shifting meanings of Melville's world, the final relation of potentially correct and incantatory concepts to this world is weakly conceived, due to the weakness of the instrument itself.—E. S. T. (shrink)

Moral case deliberation (MCD) is a specific form of clinical ethics, aiming to stimulate ethical reflection in daily practice in order to improve the quality of care. This article focuses on the implementation of MCD in nursing homes and the questions how and where to organize MCD. The purpose of this study was to evaluate one way of organizing MCD in two Dutch nursing homes. In both of these nursing homes the MCD groups had a heterogeneous composition and were organized (...) apart from existing institutional communication structures. As part of a naturalistic evaluation, systematic observations, interviews and focus groups were completed. The findings indicate that the heterogeneous composition and MCD meetings separate from existing structures have benefits. However, the participants also reported negative experiences. This gives rise to the question whether a mixed MCD group which meets separately is an effective way to embed MCD as an instrument for reflection on moral issues in daily practice. We conclude that there is no single answer to that question. In the end, the two implementation strategies (i.e. within existing communication structures and a mixed MCD group) can be complementary to each other. (shrink)

In his article “Explanation Sketches” [3], Fred Newman argues that Scriven is mistaken in his interpretation of Hempel's notion of explanation sketch. According to Scriven, to complete an explanation is to fill in further initial conditions so that the explanandum of the sketch would be entailed by the new enlarged set of initial conditions. The point may be alternatively put by saying that according to Scriven to have a complete explanation is to have a covering-law which connects initial conditions with (...) the explanandum of the original sketch. Now Scriven's point against the deductive theory as applied to History is just that very often when we try to complete a given explanation sketch, we only succeed in unearthing a law which is either false or else trivial. Newman, however, contends that this is an excusable but, nevertheless, unsympathetic way of interpreting Hempel. He suggests an alternative account to the effect that to complete an explanation we need not necessarily produce a covering-law connecting initial conditions with the explanandum; all we need to do is to mention other initial conditions and certain laws which need not necessarily contain mention of the explanandum of the sketch. As he himself puts the point: “However, generously interpreted, when Hempel speaks of a sketch vaguely indicating laws we may take him as merely suggesting that some laws are vaguely indicated which would make up the explanans of an explanation of the event in question—not necessarily in the terms which describe the event in the sketch's explanandum.”. (shrink)

Contents: Wisdoms of East and West; Method of Analysis; Table of Symbolic Numbers; The Three Columns; Application of Principles to History; Astrology; Twelve ...